Chemical Study considering the impression of sodium chloride in the process of the prevention and treatment of Covid 19 virus: A Fundamental Review

Document Type : Review

Authors

1 Department of Chemistry, Faculty of Sciences, University of Qom, Qom, Iran

2 Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran.

3 Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran

10.22091/ethc.2023.9550.1003

Abstract

Regarding spread of Covid-19 and several thousands of deaths of infected people, various methods have been proposed by researchers to reduce the chances of contracting COVID-19. The aim of this study is to find a natural method using sodium chloride (table salt) to prevent the spread of the corona virus and to explain the mechanism of the method. This is a systematic review study. A search was conducted in reputable databases such as PubMed, Science Direct, Google Scholar, Scopus, and Springer on related studies without restriction of publication year. This article is a review and all ethical principles were observed in this study. Hypochlorous acid (HOCl) is a strong antimicrobial substance in the body, which is located inside neutrophils. This combination has an essential role in eliminating the corona virus in the upper respiratory system. This occurs if there are sufficient concentrations of chloride ions in the presence of the enzyme myeloperoxidase (MPO) as well as hydrogen peroxide (H2O2). Therefore, hypochlorous acid can be considered as a very strong phagocyte to help corona virus elimination. This study shows that the necessary pretreatment can be done with very simple and cheap methods, before corona virus infects the body.

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References

Baxter, A. L., Schwartz, K. R., Johnson, R. W., Kuchinski, A. M., Swartout, K. M., Srinivasa Rao, A. S., Gibson, R. W., Cherian, E., Giller, T., Boomer, H., Lyon, M. (2024). Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients. Ear, Nose & Throat Journal, 103(1_suppl), 30S-39S.
Carbajo, J. M., & Maraver, F. (2018). Salt water and skin interactions: new lines of evidence. International Journal of Biometeorology, 62(8), pp.1345-1360.
Chan, J. F. W., Kok, K. H., Zhu, Z., Chu, H., To, K. K. W., Yuan, S., & Yuen, K. Y. (2020). Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerging Microbes and Infections, 9(1), 221-236.
Chen, Y., Liu, Q., & Guo, D. (2020). Emerging coronaviruses: Genome structure, replication, and pathogenesis. Journal of Medical Virology, 92(4), 418-423.
Collins, J. R., Veras, K., Hernández, M., Hou, W., Hong, H., & Romanos, G. E. (2021). Anti-inflammatory effect of salt water and chlorhexidine 0.12% mouthrinse after periodontal surgery: a randomized prospective clinical study. Clinical Oral Investigations, 25(7), 4349-4357.
Emine, K. E., & Gulbeyaz, C. (2022). The effect of salt-water bath in the management of treatment-related peripheral neuropathy in cancer patients receiving taxane and platinum-based treatment. Explore, 18(3), 347-356.
Hojabr Rajeooni, A., & Mehrbod, P. (2020). Molecular Structure of SARS-CoV-2 Virus and the Proposed Related Drugs. Journal of Arak University Medical Sciences, 23(5), 614-631. (in Persian)
Honarmand, E., & Motaghedifard, M. H. (2015). Immobilization of a novel synthesized Schiff base on the surface of a gold electrode for the electrochemical study of adrenaline. Analytical Methods, 7(12), 4995-5005.
Honarmand, E., Motaghedifard, M. H., & Ghamari, M. (2014). Electroanalytical approach for determination of promethazine hydrochloride on gold nanoparticles-incorporated carbon paste electrode as a nanosensor. RSC Advances, 4(67), 35511.
Horowitz, S. (2010). Salt cave therapy: rediscovering the benefits of an old preservative. Alternative and Complementary Therapies, 16(3), 158-162.
Jiang, F., Deng, L., Zhang, L., Cai, Y., Cheung, C. W., & Xia, Z. (2020). Review of the clinical characteristics of coronavirus disease 2019 (COVID-19). Journal of General Internal Medicine, 35(5), 1545-1549.
Lindsey, T., & Gillette, B. (2021). The effectiveness of saltwater gargling on the prevention of upper respiratory tract infections. Osteopathic Family Physician, 13(4), 19-23.
Liu, Y. C., Kuo, R. L., & Shih, S. R. (2020). COVID-19: The first documented coronavirus pandemic in history. Biomedical Journal, 43(4), 328-333.
Pang, J., Wang, M. X., Ang, I. Y. H., Tan, S. H. X., Lewis, R. F., Chen, J. I. P., Gutierrez, R. A., Gwee, S. X. W., Chua, P. E. Y., Yang, Q., Ng, X. Y., Yap, R. K. S., Tan, H. Y., Teo, Y. Y., Tan, C. C., Cook, A. R., Yap, J. C. H., & Hsu, L. Y. (2020). Potential rapid diagnostics, vaccine and therapeutics for 2019 novel coronavirus (2019-ncov): a systematic review. Journal of Clinical Medicine, 9(3), p.623.
Panta, P., Chatti, K., & Andhavarapu, A. (2021). Do saline water gargling and nasal irrigation confer protection against COVID-19? Explore, 17(2), 127-129.
Ramalingam, S., Graham, C., Dove, J., Morrice, L., & Sheikh, A. (2020). Hypertonic saline nasal irrigation and gargling should be considered as a treatment option for COVID-19. Journal of Global Health, 10(1), 010332.
Tiong, V., Hassandarvish, P., Bakar, S. A., Mohamed, N. A., Wan Sulaiman, W. S., Baharom, N., Abdul Samad, F. N., & Isahak, I. (2021). The effectiveness of various gargle formulations and salt water against SARS-CoV-2. Scientific Reports, 11(1), 20502.
Ullah, H., Ullah, A., Gul, A., Mousavi, T., & Khan, M. W. (2021). Novel coronavirus 2019 (COVID-19) pandemic outbreak: A comprehensive review of the current literature. Vacunas (English Edition), 22(2),106-113.
Wang, G. (2016). Chloride flux in phagocytes. Immunological Reviews, 273(1), 219-231.
Wu, A., Peng, Y., Huang, B., Ding, X., Wang, X., Niu, P., Meng, J., Zhu, Z., Zhang, Z., Wang, J., Sheng, J., Quan, L., Xia, Z., Tan, W., Cheng, G., & Jiang, T. (2020). Genome composition and divergence of the novel coronavirus (2019-ncov) originating in China. Cell Host and Microbe, 27(3), 325-328.
Zou, L., Ruan, F., Huang, M., Liang, L., Huang, H., Hong, Z., Yu, J., Kang, M., Song, Y., Xia, J., Guo, Q., Song, T., He, J., Yen, H.L., Peiris, M., & Wu, J. (2020). SARS-CoV-2 viral load in upper respiratory specimens of infected patients. New England Journal of Medicine, 382(12), 1177-1179.

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