The use of Linum album Kotschy ex Bois in traditional and modern medicine and increasing some of its medicinal compounds

Document Type : Original Article

Authors

1 Department of Plant Sciences, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

2 Department of Plant Biology, Faculty of Biological Sciences, Tarbiat Modares University, P.O.Box: 14115-154, Tehran, Iran

10.22091/ethc.2024.10588.1022

Abstract

Objective: In recent years, much attention has been paid to medicinal plants. In addition the use of medicinal plants is increasing in modern medicine. Many active compounds found in medicinal plants are used as primary molecules to make drugs. Linum album is a medicinal plant of Linaceae family and one of endemic species in Iran, has podophyllotoxin (PTOX) and phenolic compounds. PTOX is a lignan compound which occurs in a few plant species and has pharmacological importance for its anticancer activities. Also, phenolic compounds and flavonoids are antioxidant agents.Manipulation of cell culture media by elicitors is one of the main strategies for inducing secondary metabolism and production of valuable metabolites. Preliminary experiments showed that the cell extract of fungal could increase lignans production.
Methods: In this research, the filtered medium of Fusarium fungus (concentration of 1% by volume) was used as a stimulus in Linum album cell culture, then the amount of podophyllotoxin was measured by high pressure liquid chromatography (HPLC) and the amount of total phenol, flavonoid and flavonol were measured by spectrophotometer.
Results: The results showed that the amount of these compounds increased due to the use of stimulants.
Conclusion: Over time, this stimulus induced the defense responses of cells and led to more production of total phenol, flavonol, flavonoids and podophyllotoxin.

Keywords

Main Subjects

References

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Ethnobiology and Biodiversity Conservation
Volume 1, Issue 3 - Serial Number 3
September 2024
Pages 32-41

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