Document Type : Original Article
Authors
1
Department of Biology, Faculty of Science, University of Jiroft, Jiroft, Iran
2
Department of Biology, Faculty of Science, University of Jiroft, Jiroft, Iran.
10.22091/ethc.2025.12847.1058
Abstract
Objective: This study aimed to evaluate the potential antidiabetic effects of the aqueous extract of Tecomella undulata (Sm.) Seem. flower in a streptozotocin-induced rat model of type 1 diabetes.
Materials and methods: Male Wistar rats were randomly assigned to four groups: (1) normal control, (2) diabetic control, (3) diabetic rats treated with Tecomella undulata (Sm.) Seem. flower extract, and (4) non-diabetic rats treated with Tecomella undulata (Sm.) Seem. flower extract. Type 1 diabetes was induced via intraperitoneal injection of streptozotocin. The therapeutic efficacy of the plant extract was assessed through measurement of fasting blood glucose, serum insulin levels, hepatic and renal function biomarkers (ALT, AST, ALP, urea, and creatinine), lipid profile parameters (total cholesterol, LDL, HDL, and triglycerides), and histopathologicals examination of pancreatic, hepatic, and renal tissues.
Results: Treatment with the aqueous extract resulted in a statistically significant increase in serum insulin and cholesterol levels, and a concomitant decrease in fasting blood glucose, and markers of hepatic and renal dysfunction in diabetic rats. Histological analysis revealed marked improvements in pancreatic islet architecture, hepatic cellular organization, and renal tubular integrity in extract-treated diabetic rats.
Conclusion: The findings suggest aqueous extract of Tecomella undulata (Sm.) Seem. flower exerts significant antidiabetic effects in type 1 diabetic rats. This plant extract may represent a promising adjunct or alternative therapeutic strategy for the management of type 1 diabetes.
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